Fig. 6
Coordination of succinate and amino acid catabolism. a Changes in the instantaneous growth rate of E. coli in glucose M9 (black), with 20 (blue), or 40 (red) mM of pyruvate. b Changes in the instantaneous growth rate of E. coli in succinate M9 (black), with 20 (blue) or 40 (red) mM of pyruvate. c Relative succinate uptake rates of E. coli in succinate M9, supplemented with 2 g/L CAA or a synthetic mix of amino acids (SAA) consisting of the same amino acids and concentrations measured in 2 g/L CAA. Error bars represent the 95% confidence interval from fitting analysis of three biological replicates (see Supplementary Fig. 21). d Dynamic relative changes in the abundance of pyruvate (blue), oxaloacetate (red) and α-ketoglutarate (brown) upon supplementation with the amino acid mixtures and succinate as the main carbon source
