Fig. 4
From: A one-gate elevator mechanism for the human neutral amino acid transporter ASCT2
Accessibility of the substrate-binding site and lipid densities. a, b Surface representation of the ASCT2C467R structure in presence of TBOA, with the transport domain in blue, the scaffold in yellow, the antennae in red, the HP2 loop in purple and TBOA in orange. The open HP2 gate provides access to the binding site from the cytoplasm (indicated by arrows). c Slice through the surface representation of ASCT2C467R (level is indicated by dashed line in panel a) with putative lipid densities surrounding the scaffold domain shown in black and TBOA as orange balls (see also Supplementary Fig. 7)
