Fig. 6
From: Modification of messenger RNA by 2′-O-methylation regulates gene expression in vivo
Proposed model. Our findings suggest that Pxdn mRNA is targeted by snoRNAs for FBL-mediated Nm modification. The presence of this Nm modification in the coding sequence leads to an increase in mRNA abundance but with suppressed translation (left). In the absence of either FBL or the snoRNA guide(s), the mRNA is not Nm-modified, resulting in lower mRNA expression, but the translational suppression is released, leading to paradoxically higher levels of protein expression (right)
