Fig. 2
Impaired mobilization of KO HSPCs from the BM into the periphery. a Comparison of WBC counts between WT and KO mice on day 5 after G-CSF treatment. n = 5. b Representative image of spleens from WT and KO mice (left) and absolute numbers of splenocytes (right) for WT and KO mice on day 5 after G-CSF treatment. n = 5. c CFU-C in the BM (femur), PB, and spleen (SP) of WT and KO mice on day 5 after G-CSF treatment. n = 5. d Comparison of WBC counts between WT and KO mice 3 h after AMD3100 treatment. n = 5. e CFU-C in the BM (femur) and PB of WT and KO mice 3 h after AMD3100 treatment. n = 5. f Comparison of WBC counts between WT and KO mice at indicated time points after 5-FU treatment. n = 5. g Representative image of the spleen from a WT or KO mouse (left) and absolute number of splenocytes (right) for WT or KO mice at indicated time points after 5-FU treatment. n = 5. h CFU-C in the BM (femur), PB, and spleen (SP) of WT and KO mice at indicated time points after 5-FU treatment. n = 5. “−“, before treatment with G-CSF or AMD3100; “ + “, after treatment with G-CSF or AMD3100. Statistical significance was assessed by two-tailed Student’s t-test. **P < 0.01. All data are presented as the mean ± SEM. Source data are provided as a Source Data File
