Fig. 4
Phc2 deficiency leads to impaired HSPC mobilization from the BM into the periphery via stronger adhesion between HSPCs and BMSCs in BM niches. a, b CFSE-labeled LSK cells from WT and KO mice were intravenously injected into lethally irradiated recipient mice. n = 5 per group. a The frequencies of CFSE+ donor cells were measured in the BM, PB and spleen (SP) of recipients at 16 h after injection. b The frequencies of donor-derived clonogenic progenitors (CFU-C) homing to the BM (femur), PB and spleen (SP) of recipients at 16 h after injection. c Relative ratio of migrated WT or KO LSK cells (LSK) through WT or KO BMSCs (Stroma). n = 9 per group. d Relative ratio of adhered WT or KO LSK to WT or KO stroma. n = 5 per group. Statistical significance was assessed by one-way ANOVA with Tukey HSD analysis. Mean values not sharing the same superscript letter (a, b) differ significantly at P < 0.05. All data are presented as the mean ± SEM. Source data are provided as a Source Data File
