Fig. 3

LtfCre^0/+; (Gt)R26Pik3ca^*H1047R; Arid1a^fl/fl gene signature correlates with invasive patient gene expression. a Distribution of TCGA-UCEC endometrioid patient tumors relative to ssGSEA score for human orthologs of LtfCre^0/+; (Gt)R26Pik3ca^*H1047R; Arid1a^fl/fl gene signature. b Clustered comparison of scaled fold-change values for signature genes between LtfCre^0/+; (Gt)R26Pik3ca^*H1047R; Arid1a^fl/fl vs. control mice and upper vs. lower quartile of UCEC endometrioid patients. EMT genes from Hallmark pathway and Mak and Tong pan-cancer gene signature are identified. c Scatter plot of Hallmark pathway GSEA Normalized Enrichment Scores (NES) from LtfCre^0/+; (Gt)R26Pik3ca^*H1047R; Arid1a^fl/fl vs. control (human orthologs) and upper quartile of UCEC endometrioid patients vs. lower quartile. d Scatter plot of Hallmark pathway GSEA NES from upper quartile of UCEC endometrioid patients vs. lower quartile and UCEC endometrioid ARID1A^mut (frameshift/truncating alterations) vs. ARID1A^wt. e Upper quartile ssGSEA-enriched UCEC endometrioid patients present with higher stage disease relative to all patients (p < 0.01, Chi-squared). f Upper quartile ssGSEA-enriched UCEC endometrioid patients have more invasive tumors relative to lower quartile patients (p < 0.05, unpaired Mann–Whitney U, one-tailed). Box-and-whiskers plotted in the style of Tukey without outliers