Fig. 2

Impact of mutations on the brain architecture. a Example of cortical heterotopia in Eml1^−/− (left) (image width 0.6 cm) and other affected brain regions mapped on a schematic representation of the sagittal plane at Lateral 0.6 mm. b Mutations having a global impact on the brain architecture (Pfn1^+/− and Camsap3^−/−) with brain parameters mapped on a schematic representation of the two coronal sections at Bregma +0.98 mm and Bregma −1.34 mm. Bar graphs detail which regions are affected using a color code corresponding to the adjusted Benjamini–Hochberg p value (BH-p). c Example of a mutation affecting a small number of parameters: the somatosensory cortex at Bregma +0.98 mm (red arrow 0.09 cm) and the cerebellum at Bregma −5.80 mm (Slitrk4^−/Y) (image width 0.3 cm). d, e Examples of mutations having a specific impact on: d the commissures (Sik3^−/− and Ank1b^−/−) (image width 0.06 cm for Sik3^−/− and Ank1b^−/−) and e the ventricles (Sgms1^−/−) (image width 0.1 cm for Sgms1^−/−). Details of measurements appear in Supplementary Fig. 2. MP refers to the Mammalian Phenotype terms used to annotate the brain abnormalities (Supplementary Data 8)