Fig. 6
From: Angptl8 mediates food-driven resetting of hepatic circadian clock in mice
Per1 deficiency impairs the resetting functions of Angptl8. a, b qPCR analyses of time-course expression of clock and metabolic genes in Per1 KO Hepa1c1c-7 hepatoma cell lines after Angptl8 shock. n = 3, *P < 0.05 and **P < 0.01 Per1 KO vs. wild type (WT) cells at the same time point. On the other hand, mice were transduced with adenovirus expressing either scramble shRNA or Per1 shRNA through tail-vein injection at the eighth day during the Angptl8 injection. c, d qPCR analyses of clock and metabolic genes expression in the liver of mice receiving 15-day injection with recombinant Angptl8 or vehicle (PBS) at ZT2. n = 3, *P < 0.05 and **P < 0.01 Ad-Per1 shRNA vs. Ad-scramble shRNA at the same time point, two-way ANOVA followed by Bonferroni’s post hoc test. All data are presented as the means ± SD. Source data are provided as a Source Data file
