Fig. 3
Saturation mutagenesis MPRA of a myocardial infarction-associated SORT1 enhancer. Expression effects of SNVs from experiments SORT1, SORT1.2, and SORT1.flip. Direction of SORT1 and SORT1.2 was from left to right in the experiments. In the SORT1.flip experiment, the direction was reversed (right to left in the figure). Highlighted area in red, close to the experimental promoter site in SORT1 and SORT1.2, is different between the SORT1/SORT1.2 and SORT1.flip experiments. In this region, JASPAR annotates an EBF1 motif (MA0154.3). A significance threshold of 10−5 was used (red vs. green vertical lines)
