Fig. 3 | Nature Communications

Fig. 3

From: Comprehensive characterization of RAS mutations in colon and rectal cancers in old and young patients

Fig. 3

Codon missense mutational profile in KRAS-, NRAS-, and HRAS-based MSI-H/low TMB (MT-L) versus MSI-H/high TMB (MT-H) status. a Frequency of missense mutations in KRAS, NRAS, or HRAS as a factor of MT-L and MT-H status and gender in colorectal cancer (CRC) patients. ***p < 0.005. b Frequency of missense mutations affecting indicated residues in KRAS and NRAS, based on MT-H versus MT-L status. c Frequency of specific missense substitution in the G12 residue of KRAS and NRAS, based on MT-H versus MT-L status. d Frequency of missense mutations analyzed by age as a continuous variable in KRAS (in MT-L versus MT-H tumors) and NRAS (in MT-L tumors)

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