Table 5 Results of the gene-level association analyses
From: A meta-analysis of genome-wide association studies identifies multiple longevity genes
Genes | Ensembl ID | Chromosome band | Tissue | OR90 | P 90 | OR99 | P 99 |
|---|---|---|---|---|---|---|---|
ANKRD31 | ENSG00000145700 | 5q13.3 | Stomach | 0.63 | 1.1 × 10 −6 | 0.61 | 9.0 × 10−4 |
BLOC1S1 | ENSG00000135441 | 12q13.2 | Adipose subcutaneous | 0.49 | 4.5 × 10 −7 | 0.56 | 0.009 |
KANSL1 | ENSG00000120071 | 17q21.31 | Skin sun exposed lower leg | 1.22 | 1.5 × 10 −6 | 1.26 | 1.9 × 10−4 |
CRHR1 | ENSG00000120088 | 17q21.31 | Nerve tibial | 1.54 | 3.4 × 10 −7 | 1.81 | 6.2 × 10−6 |
ARL17A | ENSG00000185829 | 17q21.31 | Artery aorta | 1.24 | 8.1 × 10 −7 | 1.31 | 5.9 × 10−5 |
ARL17A | ENSG00000185829 | 17q21.31 | Breast mammary tissue | 1.18 | 1.8 × 10 −6 | 1.22 | 3.2 × 10−4 |
ARL17A | ENSG00000185829 | 17q21.31 | Colon sigmoid | 1.21 | 2.2 × 10 −6 | 1.21 | 0.002 |
LRRC37A2 | ENSG00000238083 | 17q21.31 | Minor salivary gland | 1.17 | 2.2 × 10 −6 | 1.20 | 4.4 × 10−4 |
ERCC1 | ENSG00000012061 | 19q13.32 | Ovary | 1.19 | 2.8 × 10 −7 | 1.24 | 1.8 × 10−4 |
RELB | ENSG00000104856 | 19q13.32 | Lung | 0.57 | 2.0 × 10 −7 | 0.44 | 2.9 × 10−6 |
DMPK | ENSG00000104936 | 19q13.32 | Stomach | 1.64 | 1.7 × 10 −6 | 2.31 | 1.8 × 10−6 |
CD3EAP | ENSG00000117877 | 19q13.32 | Brain substantia nigra | 0.51 | 8.0 × 10 −17 | 0.36 | 3.8 × 10 −15 |
PVRL2 | ENSG00000130202 | 19q13.32 | Artery coronary | 1.36 | 5.0 × 10 −7 | 1.59 | 1.6 × 10−6 |
PVRL2 | ENSG00000130202 | 19q13.32 | Oesophagus muscularis | 1.62 | 6.6 × 10 −7 | 2.31 | 4.4 × 10 −8 |
GEMIN7 | ENSG00000142252 | 19q13.32 | Brain nucleus accumbens basal ganglia | 0.85 | 1.5 × 10−4 | 0.70 | 1.4 × 10 −7 |
BLOC1S3 | ENSG00000189114 | 19q13.32 | Oesophagus muscularis | 2.80 | 6.4 × 10 −16 | 4.47 | 1.3 × 10 −13 |
APOC2 | ENSG00000234906 | 19q13.32 | Skin not sun exposed suprapubic | 0.75 | 4.2 × 10 −7 | 0.74 | 9.3 × 10−4 |
