Fig. 7

Co-localization of association signals of the OAF locus. Regional association plots of the OAF locus in the European ancestry urinary albumin-to-creatinine ratio (UACR) GWAS (a), with OAF gene-expression levels in healthy kidney tissue sections (b), and with OAF plasma levels (c, d). The dots are colored according to their correlation r² with the index SNP estimated based on the 1000 Genomes EUR reference samples (gray for missing data). This locus has two independent pQTLs for OAF levels, where panel c shows the association between the index pQTL at the locus (rs117554512) conditioned on its secondary signal (indexed by rs508205), and panel d shows the association with a conditionally independent SNP (rs508205, r² < 0.01 in 1000 Genomes EUR). The secondary signal rs508205 has strong evidence of co-localization with the UACR association signal (posterior probability H₄ = 0.99, Methods), while the signal rs117554512 has not (posterior probability H₄ = 0). There was strong evidence of co-localization between the UACR association signal and OAF expression in kidney tissue (posterior probability H₄ = 0.97)