Fig. 5 | Nature Communications

Fig. 5

From: A conserved RNA structural motif for organizing topology within picornaviral internal ribosome entry sites

Fig. 5The alternative text for this image may have been generated using AI.

Comparison of three-way junction structures of analogous RNA domains within picornaviral IRESs. Three-dimensional structure of the three-way junction, corresponding AL motif and overall secondary structure of HAV dV (a–c), EMCV J–K domain (d–f) and FMDV dIV (g–i), respectively. Based on the structural homology with EMCV J–K domain, a model of the FMDV dIV structure was computed in silico using the FARFAR and stepwise Monte Carlo Rosetta protocols55, 56. For facile comparison, important structural features and the corresponding nucleotides are colored analogously in all figures. Solid and hollow circles depict canonical and non-canonical base-pairing interactions, respectively, and solid orange bars indicate tertiary interactions

Back to article page