Fig. 1

γ-C(sp3)–H functionalization of ketones. a Pd-catalyzed γ-arylation reaction of the ketone using glycine as a transient directing group. b Auxiliary-assisted Pd-catalyzed γ-C(sp3)–H arylation reaction of α-imino-oxy acid. c Photoredox-catalyzed γ-C(sp3)–H functionalization of α-imino-oxy acid with radical trapping reagents. d Our work proposed that α,β-desaturation initiated γ-functionalization of ketones