Fig. 3
Scope of secondary aminesa. aReaction conditions: 1 (2 equiv.), 2 (0.4 mmol), 3a (1.5 equiv.), Cu(OAc)2 (10 mol%), bpy (10 mol%), TEMPO (3 equiv.), p-TsOH (10 mol%), PhCH3 (1.5 mL), N2, 120 °C for 48 h. Isolated yields. bReaction conditions: 1 (0.4 mmol), 2 (0.4 mmol), Cu(OAc)2 (10 mol%), bpy (10 mol%), TEMPO (3 equiv.), CsOAc (20 mol%), PhCH3 (1.5 mL), N2, 120 °C for 38 h; then 3a (1.5 equiv.) is added for another 10 h. cReaction was performed on 7.14 mmol scale
