Fig. 4 | Nature Communications

Fig. 4

From: Copper-catalyzed dehydrogenative γ-C(sp3)-H amination of saturated ketones for synthesis of polysubstituted anilines

Fig. 4

Scope of tertiary aminesa. aReaction conditions: 1 (0.4 mmol), 7 (2 equiv.), 3a (1.5 equiv.), Cu(OAc)2 (10 mol%), bpy (10 mol%), TEMPO (3 equiv.), p-TsOH (10 mol%), PhCH3 (1.5 mL), N2, 120 °C for 48 h. Isolated yields. bReaction conditions: 1 (0.4 mmol), 2 (2 equiv.), Cu(OAc)2 (10 mol%), bpy (10 mol%), TEMPO (3 equiv.), CsOAc (20 mol%), PhCH3 (1.5 mL), N2, 120 °C for 38 h; Then 3a (1.5 equiv.) is added for another 10 h

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