Fig. 6
Spike-time reliability amid noise and chaos. a1 Mean somatic membrane potential correlation, rV, between independent simulations, and between decoupled replays of those simulations (network simulation identical to Fig. 5a2). a2 Difference in rV for decoupled and network simulations. a3 Schematic of network and decoupled replay simulation paradigms, including thalamic input. b Somatic membrane potentials (Vm) of three representative neurons for the time interval highlighted by the red box in a. Top: during six independent trials. Bottom: five decoupled replay trials (green) with the same presynaptic input as during the original network simulation trial (red), but with different random seeds. c Network and decoupled rV as in a, but only for the three sample neurons in b. d Top: Raster plot of spike times of the same three example neurons as in b, during 30 independent trials of evoked activity. Bottom: Decoupled replay trials (green) of the same input received during 5 of the 30 original trials (dark red). e1 Mean spike-time reliability rspike of 2024 pyramidal neurons from layers 4, 5, and 6 between independent network simulations, and between decoupled replay simulations with identical presynaptic inputs. e2 Difference between rspike of decoupled and replayed simulations. e3 Difference between rspike of decoupled and replayed simulations vs. position of somata across layers 4, 5, and 6 of microcircuit (1675 neurons)
