Fig. 7
High reliability requires recurrent cortical connectivity. a1 Overview of three simulation paradigms: spontaneous activity, network evoked activity (with network propagation intact and VPM input), and mixed replay (with network propagation replaced by replays of spontaneous activity spike trains, and VPM input). a2 Examples of population spiking activity during the three simulation paradigms. b1 Spike-time reliability, rspike, during spontaneous (blue) and evoked (purple) activity for 1675 excitatory neurons in the center of layers 4, 5, and 6. b2 Spike-time reliability, rspike, during a mixed replay with VPM input but with network propagation disabled for the same neurons as in b1. c Difference in rspike between evoked activity with and without network propagation for 1892 excitatory neurons in the center of layers 4, 5, and 6 (same for d1–3). d1 The number of presynaptic VPM fibers from which each neuron receives input vs. rspike in evoked simulations with (network) and without (mixed replay) network propagation. All reliabilities per neuron (points) are based on 30 trials. Mean of neurons per bin indicated by line; shaded area depicts standard error of mean of neurons in bin. Bins: 0–4, 5–9, 10–14, 15–19, 20–24, 25–29, 30+ VPM fibers
