Fig. 10 | Nature Communications

Fig. 10

From: Oligodendrocyte precursor cells present antigen and are cytotoxic targets in inflammatory demyelination

Fig. 10

MS lesions have high PSMB8 expression in oligodendrocytes lineage cells. a Postmortem tissue from healthy controls or MS patients’ normal appearing white matter (NAWM) and white matter lesions (WML) was analyzed for the immunoproteasome specific subunit, PSMB8 and proteolipid protein (PLP) (scale bar 200 μm). b PSMB8 staining colocalization with SOX10 staining. c, d Quantification of imaging. A total of eight healthy controls, ten NAWM and seven WML sections were counted. Significance was determined by one-way ANOVA analysis followed by Tukey’s multiple comparison analysis (P*≤0.05, **≤0.01, ***≤0.001, ****≤0.0001). Error bars in all graphs represent standard deviation

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