Table 1 Demographic and clinical characteristics: preoperative RAS inhibitors

From: Perioperative use of renin-angiotensin system inhibitors and outcomes in patients undergoing cardiac surgery

 

Unadjusted

Inverse probability weighted adjusted

Matched data

PreRASi (n = 3603)

No-PreRASiI (n = 4978)

p-value

PreRASi (n = 3603)

No-PreRASi (n = 4978)

p-value

PreRASi (n = 3284)

No-PreRASi (n = 3284)

p-value

Age

65.9 ± 11.7

64.8 ± 13.6

<0.0001

65.6 ± 18.9

65.3 ± 17.2

0.34

65.9 ± 11.8

66.0 ± 12.4

0.70

Male

68.9

67.4

0.14

68.2

68.0

0.83

68.4

68.7

0.83

BMI

29.2 ± 6.2

28.6 ± 6.2

<0.0001

28.9 ± 9.5

28.9 ± 8.3

0.74

29.1 ± 6.1

29.1 ± 6.3

0.88

Diabetes

38.7

27.6

<0.0001

32.9

32.5

0.60

35.8

35.2

0.66

Smoker

40.7

39.5

0.26

40.3

40.1

0.72

40.2

40.4

0.92

Hypertension

87.3

69.9

<0.0001

78.4

77.4

0.14

86.2

87.0

0.35

Cerebrovascular disease

18.1

15.4

0.001

16.8

16.7

0.83

17.5

17.1

0.70

Peripheral arterial disease

13.9

11.6

0.002

12.7

12.6

0.91

13.4

12.8

0.49

Chronic lung disease

18.8

20.1

0.04

20.3

19.8

0.49

19.6

19.7

0.90

Family history CAD

40.5

38.3

0.04

39.7

39.3

0.58

40.6

41.3

0.58

Angina

37.2

34.6

0.02

36.1

35.9

0.73

37.8

38.3

0.51

Congestive heart failure

32.7

28.6

<0.0001

31.4

30.7

0.30

30.7

30.5

0.89

Previous MI

36.4

30.2

<0.0001

33.5

33.0

0.47

35.0

35.1

0.94

Beta blockers

72.6

63.3

<0.0001

68.9

67.6

0.09

71.4

71.5

0.87

Aspirin

75.9

66.6

<0.0001

71.3

70.7

0.34

74.5

74.5

0.98

Lipid lowering

82.2

74.1

<0.0001

78.3

77.7

0.35

81.1

81.5

0.73

Urgent

49.9

52.9

0.01

51.7

51.6

0.86

51.1

51.9

0.52

CABG

49.5

51.9

<0.0001

55.3

55.0

0.76

58.3

58.5

0.84

Valve

24.0

29.3

<0.0001

27.0

27.1

0.90

24.8

24.9

0.93

Post RAS inhibitor

46.0

25.6

<0.0001

45.8

26.7

<0.0001

46.0

28.5

<0.0001

Cardiopulmonary bypass time

130.7 ± 80.5

126.3 ± 79.6

0.012

128.2 ± 121.1

128.3 ± 107.0

0.96

127.5 ± 77.8

126.3 ± 79.7

0.52

Cross clamp time

93.8 ± 59.5

90.8 ± 58.9

0.020

92.3 ± 90.2

92.2 ± 79.3

0.97

91.8 ± 58.1

90.9 ± 58.9

0.53

Number of artery grafts

  

0.012

  

0.80

  

0.14

  None

45.7

48.8

 

46.7

47.2

 

46.2

48.2

 

  1

45.5

42.4

 

44.4

44.0

 

45.3

42.8

 

  2 or more

8.8

8.8

 

8.9

8.8

 

8.5

8.9

 

On-off pump

  

0.0021

  

0.80

  

0.39

  Off pump

6.5

6.7

 

6.4

6.5

 

6.7

6.2

 

  On pump (full)

93.5

93.3

 

93.6

93.5

 

93.3

93.8

 
  1. Values are mean ± SD or %. C-index = 0.74. p-values are obtained via analyses using Pearson chi-square test or Wilcoxon rank-sum test (unadjusted) and then IPW or PSM (adjusted)
  2. BMI body mass index, MI myocardial infarction
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