Table 3 Preoperative RAS inhibitors and postoperative outcomes

Outcome n (%)	Unadjusted				IPW adjusted		One-to-one matched
Outcome n (%)	RASi (N = 3603)	Non RASi (N = 4978)	OR 95% CI	p-value	OR 95% CI	p-value	RASi (N = 3284)	Non RASi (N = 3284)	OR 95% CI	p-value
MACE	417 (11.6)	650 (13.1)	0.87 (0.76–0.99)	0.04	0.89 (0.81–0.97)	0.01	377 (11.48)	419 (12.76)	0.90 (0.77–1.05)	0.19
Perioperative MI	29 (0.80)	39 (0.78)	1.03 (0.63–1.67)	0.91	1.07 (0.76–1.48)	0.69	26 (0.79)	25 (0.76)	1.02 (0.58–1.78)	0.95
Heart block	51 (1.42)	58 (1.17)	1.22 (0.83–1.78)	0.31	1.50 (1.16–1.94)	0.01	48 (1.46)	40 (1.22)	1.19 (0.77–1.82)	0.42
Cardiac arrest	86 (2.39)	113 (2.27)	1.05 (0.79–1.40)	0.72	1.11 (0.91–1.41)	0.29	80 (2.44)	67 (2.04)	1.28 (0.92–1.79)	0.47
Permanent stroke	68 (1.89)	111 (2.23)	0.84 (0.62–1.14)	0.27	0.85 (0.69–1.01)	0.13	59 (1.80)	68 (2.07)	0.88 (0.62–1.25)	0.47
TIA	15 (0.42)	24 (0.48)	0.86 (0.45–1.65)	0.66	0.90 (0.57–1.43)	0.66	12 (0.37)	13 (0.40)	0.91 (0.41–2.02)	0.77
Coma	26 (0.72)	40 (0.80)	0.90 (0.55–1.47)	0.67	0.88 (0.62–1.25)	0.63	21 (0.64)	21 (0.64)	1.09 (0.59–2.03)	0.99
Renal failure	167 (4.64)	258 (5.18)	0.89 (0.73–1.09)	0.25	0.86 (0.75–0.97)	0.03	148 (4.51)	168 (5.12)	0.91 (0.72–1.15)	0.42
Total hrs ICU mean ± SD	112.4 ± 186	116.7 ± 179	4.51 (−3.27–12.3)	0.26	−1.94 (−10.4–6.2)	0.64	112.1 ± 188	112.6 ± 167	0.55 ± 178	0.90
Readmission	502 (13.93)	624 (12.54)	1.13 (0.996–1.28)	0.06	1.10 (1.01–1.21)	0.02	467 (14.22)	428 (13.03)	1.10 (0.95–1.27)	0.20
30-day mortality	128 (3.55)	251 (5.04)	0.69 (0.54–0.85)	0.01	0.67 (0.58–0.76)	<0.0001	112 (3.41)	165 (5.02)	0.69 (0.54–0.90)	0.01

Values are mean ± SD or number or %. p-values are obtained via analyses using Pearson chi-square test or Wilcoxon rank-sum test (unadjusted) and then IPW or PSM (adjusted)
MACE major adverse cardiovascular events, MI myocardial infarction, TIA transient ischemic attack

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