Fig. 2

The landscape of structural variants (SVs) in MM. a Top, prevalence of SVs across the entire series. Bottom, the proportion of SVs shared between samples collected at different time points within the same patients. b A heatmap representing the distribution and prevalence of the main complex events: chromothripsis, chromoplexy, and templated insertions. c Three examples of chromothripsis. In these plots, the red arch represents a deletion, the green arch represents an internal tandem duplication (ITD) and the blue arch represents an inversion. d Example of templated insertion. In the middle, the genome plot of patient PD26422 represents all main genomic events: mutations (external circle), indels (middle circle; dark green and red lines represent insertions and deletions respectively), copy-number variants (red = deletions, green = gain) and rearrangements (blue = inversions, red = deletionss, green = ITDs, black = translocations). Externally, a copy-number/rearrangement plot of each chromosome involved in the templated insertion is provided, highlighting a focal CNA around each breakpoint. This case represents a clear example of how templated insertion may involve critical driver oncogenes, like CCND1 in this case. A schematic representation of this sample templated insertion is reported on the right