Fig. 4

The chronological reconstruction of aneuploidies acquisition in MM. a Heatmaps representing the cumulative acquisition of copy-number gains observed in 13/18 hyperdiploid patients, labeled in red if the final HRD profile was generated by multiple and independent events (n = 13) or green if the trisomies were acquired in one single time window (n = 5). Boxes are color-coded based on the relative order of acquisition of each event; WCD = whole chromosome duplication. b A Bradley–Terry model based on the integration between the CCF and molecular time of each recurrent CNAs (gains = red and deletions = blue) for all 30 MM cases included in this study. Segments were ordered from the earliest (top) to the latest (bottom) occurring in relative time from sampling. The time scale (X-axis) is relative since timing of genomic evolution is variable from case to case and not easily correlated to age. c Cancer cell fraction of each single complex event for each patient over the time