Fig. 6

The chronological reconstruction of driver events in MM. Phylogenetic trees generated from the Dirichlet process analysis (“Methods”). The root (always colored in red) and branch length are proportional to the (sub)clone mutational load. All main drivers (CNAs, SNVs, and SVs) were annotated according to their chronological occurrence. Early clonal events (root) were chronologically annotated on the right, when it was possible to establish a specific time window. Here, all different root time windows were separated by a green line. Conversely, early drivers without a clear timing were grouped together on the left of the root. All driver events that occurred in the root were reported with larger font size. Patients were grouped according to the genomic clustering shown in Fig. 1c, and color-coded accordingly. TI = templated insertion