Table 2 Summary of significant known and novel loci from analysis of common variants

From: Mapping eGFR loci to the renal transcriptome and phenome in the VA Million Veteran Program

 

Number of loci

Average effecta (SD)

P-values*

Known loci

54

0.49 (0.28)

0.0025

Novel loci

64

0.38 (0.17)

 

Tier 1

79

0.45 (0.26)

 

Tier 2

28

0.41 (0.19)

 

Tier 3

11

0.36 (0.10)b

 

Diabetics

35

0.90 (0.61)

0.001

Non-diabetics

98

0.52 (0.28)

 
  1. Tier 1 = First tier significance criteria: GWAS significance at discovery + replicationpassing Bonferroni threshold + consistent directions of associations between discovery and replication sets
  2. Tier 2 = Second tier significance criteria: GWAS significance at discovery + replication p between 5 × 10−8 and 0.00040004 + consistent directions of associations between discovery and replication sets 
  3. Tier 3 = Third tier significance criteria: GWAS significance at discovery + replication p between 0.0004 and 0.05 + consistent directions of associations between discovery and replication sets 
  4. *P-value from two-sample t-test comparing mean effect estimates
  5. aAverage effect = average and standard deviation of the absolute value of beta-estimates from MVP, in mL/min/1.73 m2
  6. bExcluding two extreme outliers
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