Fig. 1

Landscape of metabolic gene expression at single-cell level. a Schematic representation of the scRNA-seq data analysis pipeline. b Numbers of each type of cells in the melanoma dataset. c Numbers of each type of cells in the head and neck squamous cell carcinoma (HNSCC) dataset. d t-SNE plot of metabolic gene expression profiles of malignant cells from the melanoma dataset. The color of each dot indicates the tumor which the cell comes from. e Same as in d but for the HNSCC dataset. f Clustered correlation matrix showing Spearman’s rank correlation coefficients of metabolic gene expression profiles between malignant cells in the melanoma dataset. g Same as in f but for the HNSCC dataset. h t-SNE plot of metabolic gene expression profiles of non-malignant cells from the melanoma dataset. The color of each dot indicates the tumor which the cell comes from. i Same as in h but for the HNSCC dataset