Fig. 4
From: B1 oligomerization regulates PML nuclear body biogenesis and leukemogenesis
SAXS and cross-linking assays of PML B1-box oligomerization. a–c SAXS analysis of WT B1 (a), B1 W157E (b), and B1 F158E (c). The experimental data are shown in black dots. The theoretical scattering pattern derived from PML B1 multimers is shown in red line. Bottom-left panels of each figure, the oligomeric distribution/dynamic in solution. Source data are provided as a Source Data file. d Statistical summary of SAXS experiments. e, f Oligomerization-dependent crosslinking assays. In e, PML B1 and mutants were cross-linked by an increased concentration of glutaraldehyde (GA). In f, PML1–256 and mutants were cross-linked by an increased concentration of glutaraldehyde (GA). The poly-B1 and poly-PML1–256 are highlighted with brackets and red boxes. Source data are provided as a Source Data file
