Table 3 Cox proportional hazards model for disease-specific survival

From: Retrotransposon insertions can initiate colorectal cancer and are associated with poor survival

 

Coefficient

Std. err.

z

p

HR [95% CI]

Signif.

Insertion count (/10)

0.108

0.0362

2.98

2.93e-03

1.11 [1.04, 1.20]

**

MSI

−0.258

0.642

−0.402

6.88e-01

0.773 [0.219, 2.72]

 

CIMP-H

0.174

0.341

0.510

6.10e-01

1.19 [0.610, 2.32]

 

BRAF mutation

0.790

0.447

1.77

7.68e-02

2.20 [0.918, 5.29]

.

Age [55, 75) years

−0.147

0.408

−0.360

7.19e-01

0.863 [0.388, 1.92]

 

Age ≥ 75 years

0.188

0.427

0.439

6.60e-01

1.21 [0.523, 2.78]

 

Male

0.311

0.232

1.34

1.80e-01

1.37 [0.866, 2.15]

 

Dukes B

0.452

0.449

1.01

3.13e-01

1.57 [0.652, 3.79]

 

Dukes C

1.77

0.431

4.12

3.82e-05

5.89 [2.53, 13.7]

***

Dukes D

2.78

0.454

6.12

9.07e-10

16.2 [6.64, 39.4]

***

Allelic Imbalance (/10% of reference)

−0.0583

0.0539

−1.08

2.80e-01

0.943 [0.849, 1.05]

 
  1. The model was stratified by tumor location
  2. HR Hazard ratio, CI confidence interval, MSI microsatellite instability, CIMP-H CpG island methylator phenotype high
  3. Significance codes:  *** ≤ 0.001 < ** ≤ 0.01 < * ≤ 0.05 < . ≤ 0.1
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