Fig. 2 | Nature Communications

Fig. 2

From: Structural basis of Cullin 2 RING E3 ligase regulation by the COP9 signalosome

Fig. 2

Structure of the deneddylated CSN–CRL2 complex. a The fitted density map of deneddylated CSN–CRL2 structure determined by combining cryo-EM and XL-MS. Alignment of the CSN C-terminal helical bundle from the neddylated and deneddylated holocomplexes reveals differences in b CSN2 and c CUL2. d CSN1-ELOB interface established from the rotation of CUL2 in c. e RBX1 is clamped between CSN2 and CSN4. f Conformational changes in CSN6 in the absence of NEDD8

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