Fig. 1 | Nature Communications

Fig. 1

From: Tuberculous meningitis in children is characterized by compartmentalized immune responses and neural excitotoxicity

Fig. 1The alternative text for this image may have been generated using AI.

Whole blood transcriptome in pediatric TBM cases and IGRA-negative controls. a Principal component analysis on 2230 differentially expressed genes between TBM and healthy controls. b Deconvolution analysis revealed the in silico cellular composition of whole blood RNA. c Ingenuity canonical pathways overrepresented by differentially expressed genes are shown. The z-score indicates whether the pathway was upregulated (red) or downregulated (blue) in TBM. d Inflammasome signaling pathway is depicted. Molecules colored in red were significantly upregulated in TBM, compared to the controls. e T-cell activation pathway is shown. Molecules colored in blue were significantly downregulated in TBM, relative to the healthy controls

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