Fig. 3
From: EZHIP constrains Polycomb Repressive Complex 2 activity in germ cells
EZHIP-mediated interplay between H3K27me2 and H3K27me3. a Genome-browser representation of H3K27me3 enrichment in U2OS WT, EED−/−, and EZHIP−/−. Duplicates are merged, same scale for all tracks. b Corresponding Genome-browser representation of H3K27me2, H3K27Ac, and H2AK119ub in U2OS WT and EZHIP−/−. Duplicates are merged. Same scale for all tracks of the same histone modification. c, d Heatmaps and corresponding cumulative plots showing the enrichment for H3K27me3 (c) and, H3K27me2, H3K27Ac, and H2AK119ub (d) at the peaks (n = 34220) found to gain H3K27me3 upon deletion of EZHIP. e Density plots showing the enrichment for H3K27me3, H3K27me2, H3K27ac, and H2Aub around the TSS of genes either upregulated or downregulated upon known out of EZHIP as defined in Fig. 2d
