Fig. 7
From: EZHIP constrains Polycomb Repressive Complex 2 activity in germ cells
Characterization of Ezhip−/− oocytes. a Mean-difference plot showing log2 fold-change (logFC) expression vs. average log2 counts per million (logCPM) for MII oocytes obtained from 4 weeks Ezhip + /− and Ezhip−/− superovulated females, n = 2 (each n is a pool of two individual animals). b Expression vs. log2 fold-change (logFC) expression vs. average log2 counts per million (logCPM) for MII single oocyte obtained from 4-month-old Ezhip + /− and Ezhip−/− superovulated females, n = 9 for WT and n = 10 for Ezhip−/−. Oocytes originated from two different mice for WT and 3 for Ezhip−/−. c Principal components analysis of each individual oocyte transcriptome. d Mos expression according to the single oocyte RNAseq included in (c). e Chromosome abnormalities evaluated as a proportion of matured MII stages oocytes that exhibited normal alignment of chromosomes on spindle vs. matured MII stages oocytes with lagging chromosomes
