Fig. 8
From: EZHIP constrains Polycomb Repressive Complex 2 activity in germ cells
Ezhip knockout affects adult female fertility. a Follicle counting on WT vs. Ezhip−/− 2 week-old female slides and 16-week-old, upper and lower panel, respectively (eight slides counted for each genotype, mean ± s.d.). Left panel corresponds to the total number of follicles, then each panel corresponds to a different folliculogenesis step: primordial follicles, primary follicles, secondary/antral follicles. Y-axis represents the average follicles number per slide, genotype is indicated in the legend. b Average ovaries weight (mg) in adult females (4–5-month-old, mean ± s.d., each dot represents an independent female). c–e Fertility of WT and Ezhip−/− females monitored during 5 months. c Cumulative number of pups per genotype depending on time (n = 13 cages, breeding scheme represented on top). d The number of litters per female during the 20 weeks monitoring. e Litter size. a, b, d, e Significance: unpaired, non-parametric test of Kologorov–Smirnov, ***P ≤ 0.001, **P ≤ 0.01
