Fig. 5 | Nature Communications

Fig. 5

From: A phenotypic and genomics approach in a multi-ethnic cohort to subtype systemic lupus erythematosus

Fig. 5The alternative text for this image may have been generated using AI.

Identification of candidate cluster-associated cg07259759 (USP35) that mediates genetic association of rs7104222 (GAB2) with clusters. Association of DNA methylation of cg07259759 and cluster (a) or genotype of rs7104222 (b). c Association between genotype rs7104222 and clusters. d Beta coefficient represents the dependence of cluster on genotype with or without adjusting for methylation. Error bars represent the 95% confidence interval for beta coefficient estimate. After adjusting for methylation, the observed dependence reduces toward zero

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