Fig. 4 | Nature Communications

Fig. 4

From: Identification of somatic mutations in single cell DNA-seq using a spatial model of allelic imbalance

Fig. 4The alternative text for this image may have been generated using AI.

SCAN-SNV workflow. GATK HaplotypeCaller determines sites with non-reference evidence and discovers germline or clonal hSNPs from bulk. Phased hSNPs serve as a training set to learn AB correlation patterns, predict AB at candidate sSNV loci and estimate artifact prevalence. Only candidate sSNVs passing all filters are reported as putative mutations

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