Fig. 7

Distinct chemokine receptor imprint of CD56^bright natural killer (NK) cells during acute dengue virus (DENV) infection. a Representative histograms showing chemokine receptor staining on responding (Ki67⁺, red) and non-responding (Ki67⁻, blue) CD56^bright NK cells and the respective fluorescence minus one (FMO) controls (gray). b Heat map summarizing (median) the expression of each of the 12 chemokine receptors on CD56^bright (left) and CD56^dim (right) NK cells. This is subdivided into Ki67^+/− (two left panels) and CD69^+/− (two right panels) during the acute phase compared to the post-febrile and convalescent phase of DENV infection (n = 10–21) and healthy controls (n = 12–16). Frequencies are shown for all chemokine receptors except CLA, CX3CR1, and CCR10. Statistical differences were tested using paired t test or Wilcoxon’s matched-pairs signed-rank test and unpaired t test or Mann–Whitney test. Stars (*) represents Ki67⁺ and CD69⁺ compared to Ki67⁻ and CD69⁻, respectively. *P < 0.05, **p < 0.01, and ***p < 0.001. Hashes (#) represent Ki67⁺or CD69⁺ compared to healthy controls, ^#p < 0.05, ^##p < 0.01, ^###p < 0.001. Source data are provided as a Source Data file