Fig. 7
From: SOX11 and SOX4 drive the reactivation of an embryonic gene program during murine wound repair
Identification of direct targets of SOX11 and SOX4 in embryonic epidermis. a Top Venn diagram shows the overlap of SOX4/11-bound targets (ChIP-seq) and transcripts in dcKO E16.5 epidermis whose expression is changed >1.5-fold (log2-fold change) and FDR < 0.05. The bottom Venn diagrams show the overlap between the SOX11- and SOX4- directly regulated targets and the differentially expressed genes in E13.5 epidermal cells. Statistically significant p values and the enrichment level R values are highlighted in red. b GO enrichment analyses of the 487 direct targets of SOX11 and/or SOX4 in embryonic epidermal progenitors (from Fig. 7a), highlighting categories related to cell cytoskeleton and movement (blue) and epidermal development (red), as determined by Metascape, q values < 0.05. c SOX11 and SOX4 ChIP-seq tracks displaying shared SOX11- and SOX4-bound genomic regions in the EDC locus. Sprr and Lce family gene clusters are shown at higher magnification below. d Schematic representation of the epidermal differentiation cluster (EDC) on mouse chromosome 3. Late-stage differentiation EDC genes that were highly upregulated in dcKO epidermis at E16.5 are marked in red. They are also listed in Supplementary Table 2. Source data for panel a are provided as a Source Data file
