Fig. 1
From: EGR1 recruits TET1 to shape the brain methylome during development and upon neuronal activity
Methylation dynamics of EGR1 binding sites during mouse brain development. a EGR1 binding motif (E value = 1.1e−252) identified from ChIP-seq data generated with mouse adult frontal cortices. b Genomic distribution of EGR1 peaks. c Distribution of histone marks H3K27ac, H3K4me1, and H3K4me3 surrounding EGR1 peaks. d Methylation dynamics of EGR1 binding sites during brain development from embryonic day 11.5 to 22 months, in neurons (NeuN+), and non-neuronal cells (NeuN−). e Correlation of methylation changes at EGR1 binding sites during mouse brain development and between cell specification. Only binding sites with at least ten methylation calls in all four methylomes were included. P-values were determined with Wilcoxon Rank Sum Test
