Fig. 3

Non-random processes impact the emergence and disruption of Pribnow boxes. a Distribution of new (green) and disrupted (purple) Pribnow boxes in 1000 random simulations. Red arrows mark the observed value for each type of event in our dataset. b Mutation bias towards new A and T alleles inferred from 235,212 substitution obtained from 4595 clinical samples of the MTBC and normalised by GC content as in ref. 20