Fig. 1
A pipeline for surveying the impact of 2009 SNVs on protein–protein interactions. a Phenotypic consequences of coding variants in human genotypes can be interpreted as products of protein–protein interaction perturbations in the interactome. b Over half of all unique missense variants in ExAC are singletons. To avoid oversampling very rare variants from ExAC, 1676 ExAC variants were selected across a wide range of allele frequencies. 204 disease-associated mutations listed in HGMD and 162 cancer somatic mutations from COSMIC were also examined. c Pipeline for testing the functional impact of 2009 SNVs on protein interactions and stability impact of 278 population variants by dual-fluorescence screen
