Fig. 4
From: Potent antibody lineage against malaria transmission elicited by human vaccination with Pfs25
Molecular definition of the interaction between mAb 2544 and Pfs25. a Plot of buried surface area (BSA) of the 2544-Pfs25 complex crystal structure. BSA is separated into total interaction of heavy chain (dark teal) and light chain (light teal). Chains are further delineated into the amount of BSA per CDR, as labeled. The total number of hydrogen bonds and salt bridges per chain and CDR is listed above each bar. b Interaction between the 2544 HCDR3 (dark teal) and Pfs25 (gray). Both proteins are displayed as cartoons, and the side chains or main chain of residues that form hydrogen bonds are displayed as sticks. Hydrogen bonds are denoted by black dashes. c Interactions between 2544 HCDR2 (dark teal) and Pfs25 (gray). d Interactions between 2544 κCDR1/κCDR3 (light teal) and Pfs25 (gray)
