Fig. 6
From: Potent antibody lineage against malaria transmission elicited by human vaccination with Pfs25
The 2544 lineage shows potent SMFA activity. a Phylogenetic tree of the 2544 lineage. The gray, leftmost circle refers to the position of the inferred germline precursor. Red circles indicate sequenced members of the lineage; the length of blue lines represents the evolutionary distance from germline. Antibodies chosen for further characterization are denoted by a black circle and labeled. 2544 is displayed as a teal square. b Transmission-reducing activity (in percentage) for gl2544 (gray), germline mutants (gray), and 2544-lineage member mAbs (black) in SMFA at 50 µg/mL. KD for each Fab binding to recombinant Pfs25 is denoted above its bar of SMFA activity. NB, no binding constant measured. Data are the result of two separate feeds, and the best-estimate (circles) and the 95% CI (error bars) of %TRA values are shown
