Fig. 6

TTC36 deficiency in mice results in impaired learning and memory. a Mean escape latency per training block for the aged wild-type and Ttc36^−/− mice (8–12 months, WT group: n = 13, Ttc36^−/− group: n = 11), Mean ± s.e.m. b Mean escape latency for the aged wild-type and Ttc36^−/− mice (8–12 months, WT group: n = 13, Ttc36^−/− group: n = 10) during retention probe trial, Mean ± s.e.m. c Nest construction was quantified in aged wild-type and Ttc36^−/−mice (8–12 months, WT group: n = 14, Ttc36^−/− group: n = 7) mice. Data from panels a and c are analyzed by two-way ANOVA with Sidak’s post-hoc test. **P < 0.01. d Schematic for HPD degradation regulated by the TTC36-STK33-PELI1 signaling axis in tyrosinemia, inducing neurological damage and disorders