Table 1 Percentage of established lipid-associated loci with evidence of reproducibility in target studies

From: The transferability of lipid loci across African, Asian and European cohorts

P in GLGC:

<10−100

≥10−100

Study

Trait

n.s.a

Regionb

Crediblec

n.s.a

Regionb

Crediblec

UKHLS

HDL

5.9

17.6

76.5

81.0

13.7

5.2

 

LDL

7.7

15.4

76.9

77.0

16.4

6.6

 

TG

0.0

5.3

94.7

82.1

14.5

3.4

CKB

HDL

11.8

5.9

82.4

71.2

16.4

12.4

 

LDL

7.7

30.8

61.5

83.6

7.4

9.0

 

TG

5.3

15.8

78.9

82.9

10.3

6.8

BBJ

HDL

11.8

11.8

76.5

47.7

19.6

32.7

 

LDL

7.7

30.8

61.5

64.8

10.7

24.6

 

TG

5.3

10.5

84.2

55.6

12.8

31.6

APCDR-Uganda

HDL

11.8

17.6

70.6

73.2

25.5

1.3

 

LDL

23.1

7.7

69.2

73.8

24.6

1.6

 

TG

42.1

47.4

10.5

79.5

17.1

3.4

  1. Only one SNP was kept for each locus with multiple associated variants in close proximity. Regions were defined as 25 Kb either side of the lead variant. The credible set contains the reported lead variant and variants in LD (r2 > 0.6) with it. Results are shown separately for groups of loci by strength of association (whether p < 10−100) in the discovery study (GLGC). There were 25, 16, and 27 loci with p < 10−100 based on a score test in GLGC for HDL, LDL, and TG, respectively. There were 212, 171, and 158 loci with p≥10−100 for HDL, LDL, and TG, respectively
  2. aNo variant in the region associated in target set at p < 10−3
  3. bNo variant in the credible set associated in the target set at p < 10−3 but an uncorrelated variant in the region is associated in target set at p < 10−3
  4. cA variant in the credible set is associated in the target set at p < 10−3
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