Fig. 3
From: Inferring neural signalling directionality from undirected structural connectomes
Send-receive communication asymmetry in the human connectome (N = 360 at 15% connection density). a Cortical projection of send-receive asymmetry values under navigation. Regions associated with significant send-receive asymmetry are classified as putative senders (orange) and receivers (blue). Regions colored gray are neutral and do not show significant send-receive asymmetry. b Scatter plot showing correlation between send (vertical axis) and receive (horizontal axis) efficiency across regions under navigation. Send and receive efficiency values were aggregated across all individuals for each region. Markers are colored according to send-receive asymmetry values (colors approximately match that of panel a). Small, medium and large markers represent nodes with low (κ < 50), medium (50 ≤ κ ≤ 100) and high (κ > 100) degree, respectively. The dashed line marks the x = y identity line. The distance between markers and the identity line provides a geometric interpretation of regional bias towards sending (x < y) or receiving (x > y) efficiencies. c Top: Distribution of the cortical gradient eigenvectors used as a measure of functional heterogeneity35. Bottom: Violin plots showing distribution of send-receive asymmetries for regions classified as unimodal (red), transitional, (beige) and multimodal (blue) regions. Horizontal bars and white circles denote, respectively, the mean and median of the distributions. Stars denote significant differences in between-group medians given by a two-sided Wilcoxon rank sum test (one, two and three stars denote P < 0.05, 0.005, 0.0005, respectively). d, e Search information equivalent of a–c. (g–i) Diffusion efficiency equivalent of a–c
