Fig. 3
From: Characterizing rare and low-frequency height-associated variants in the Japanese population
Summary of gene-based analysis. a Manhattan plot of the gene-based test. The yellow line represents significance threshold (P < 2.5 × 10−6). b Comparison of single-variant test P values and those of the gene-based test. Two genes (SLC27A3 and CYP26B1) showed much stronger associations in the gene-based test. c, d Positions and associations of nonsynonymous variants in SLC27A3 and CYP26B1. The colors of the plots denote the impact of the variants. The symbols (circle, diamond, and square) indicate the function of variants. The coding regions are colored according to their structural domains based on Pfam
