Fig. 5 | Nature Communications

Fig. 5

From: The cryo-EM structure of the acid activatable pore-forming immune effector Macrophage-expressed gene 1

Fig. 5

Schematic illustrating two proposed mechanisms for control of MPEG1 function. a MPEG1 prepores (alternate subunits coloured) are localised to the phagolysosome membrane, either through the transmembrane helix or the MABP β-hairpin. Upon acidification or proteolytic activity, the prepores are released from the membrane into the phagosome lumen. Via an unknown means these recognise engulfed target membranes and form pores. b Alternatively, prepores remain tethered to the phagosome membrane inner leaflet via the MABP β-hairpin and are triggered to form pores in engulfed bacteria upon acidification

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