Fig. 3
From: Optimized CRISPR guide RNA design for two high-fidelity Cas9 variants by deep learning
Analysis of feature importance associated with gRNA activity by Tree SHAP. a–c Top 20% important features identified by Tree SHAP for WT-SpCas9, eSpCas9(1.1), and SpCas9-HF1, respectively. The nucleotides, as well as their position, were shown on the left. GG_19 means GG dimer start at position 19. Tm means melting temperature
