Table 2 Fat-induced and non-fat-induced MYC signature score in relation to risk of prostate cancer death among men diagnosed with non-metastatic prostate cancer

From: High-fat diet fuels prostate cancer progression by rewiring the metabolome and amplifying the MYC program

MYC score

n

Leading edge genes (fat-induced)a

n

Non-leading edge genes (non-fat-induced)b

OR (95% CI)c

OR (95% CI)d

OR (95% CI)e

OR (95% CI)c

OR (95% CI)d

OR (95% CI)e

Animal fat

 Tertile 1 (low)

13

1.00

1.00

1.00

17

1.00

1.00

1.00

 Tertile 2

18

1.58 (0.73, 3.53)

1.31 (0.57, 3.08)

1.27 (0.55, 2.99)

19

1.17 (0.57, 2.44)

1.03 (0.47, 2.30)

0.96 (0.43, 2.16)

 Tertile 3 (high)

31

3.44 (1.69, 7.38)

2.50 (1.14, 5.70)

2.37 (1.07, 5.43)

26

1.79 (0.90, 3.64)

1.07 (0.81, 3.70)

1.66 (0.78, 3.61)

 P, linear trendf

 

0.001

0.019

0.03

 

0.09

0.15

0.17

Saturated fat

 Tertile 1 (low)

13

1.00

1.00

1.00

16

1.00

1.00

1.00

 Tertile 2

15

1.23 (0.55, 2.80)

1.07 (0.45, 2.59)

1.05 (0.44, 2.54)

18

1.24 (0.59, 2.64)

1.17 (0.52, 2.65)

1.09 (0.48, 2.48)

 Tertile 3 (high)

34

4.02 (1.98, 8.63)

3.21 (1.47, 7.35)

3.04 (1.38, 7.01)

28

2.34 (1.18, 4.82)

1.93 (0.90, 4.23)

1.86 (0.87, 4.08)

 P, linear trendf

 

0.0001

0.002

0.004

 

0.015

0.085

0.107

  1. n lethal events, OR odds ratio; CI confidence interval
  2. aAnimal fat: n = 122; Saturated fat: n = 113
  3. bAnimal fat: n = 78; Saturated fat: n = 87
  4. cLogistic regression model adjusted for age and year at diagnosis (continuous)
  5. dLogistic regression model adjusted for age and year at diagnosis (continuous), and gleason grade (continuous: <7, 3 + 4, 4 + 3 >7)
  6. eLogistic regression model adjusted for age and year at diagnosis (continuous), gleason grade (continuous: <7, 3 + 4, 4 + 3, >7), and BMI at diagnosis (continuous)
  7. fEstimated by modeling tertiles of MYC score as continuous variable (tertile 1 = 0, tertile 2 = 1, tertile 3 = 2)
Back to article page