Fig. 7
Evolution of heritability, correlation with other traits, and risk scores at all time points. a H2 estimates based on LD score regression for BMI plotted at each time point (black) along with locally estimated scatterplot smoothing (LOESS) local regression (in blue). Error bars represent one SEM on each side of the point. b LOESS local regression of the LD score regression coefficient (rg) between the BMI association results at each time point and phenotypes from LD Hub (i) adult extreme BMI, (ii) adult BMI, (iii) leptin not adjusted for BMI, (iv) childhood obesity, (v) type 2 diabetes, T2D, (vi) fasting insulin main effect, (vii) homeostatic model assessment for insulin resistance, HOMA-IR, (viii) birth weight. c Pearson’s r correlation coefficient between polygenic risk scores (PRS) and BMI at each time point along with LOESS local regression for birth weight9 (green), childhood BMI5 (red), and adult BMI3 (blue)
